Semaglutide Alternatives Works

Unlike other medications that suppress appetite, semaglutides stimulate the body to produce more insulin, which reduces blood sugar (glucose). Semaglutide alternatives belongs to a group of drugs called GLP-1 receptor agonists, or GLP-1 RAs. It is used to treat Type 2 diabetes and for long-term weight loss in overweight or obese adults.

When given in combination with diet and exercise, semaglutide can cause weight loss and a reduced risk of cancer, diabetes and heart disease in people with obesity or overweight. It is also the first GLP-1 RA approved to help prevent weight gain in non-overweight individuals.2

In the STEP 5 study, semaglutide 2.4 mg significantly improved a wide range of cardiometabolic outcomes compared with placebo treatment (see table). Specifically, systolic and diastolic blood pressure, HbA1c, total cholesterol, very low-density lipoprotein (VLDL) cholesterol and triglycerides all decreased in those receiving semaglutide, and C-reactive protein levels — an indicator of inflammation — were significantly reduced in participants with both Type 2 diabetes and obesity.

Gastrointestinal side effects, such as nausea and vomiting, were the most common adverse events experienced by participants during the 68-week study. However, these events were typically transient and mild to moderate in severity. Furthermore, they did not lead to discontinuation of the medication.

While semaglutide is safe for most people, it may not be right for everyone. You should not use it if you have a thyroid tumor or a personal or family history of medullary thyroid cancer. In addition, you should not use it if you have certain eye problems caused by diabetes, such as diabetic retinopathy.

If you decide to try semaglutide, talk with your primary care physician (PCP) or endocrinologist about possible risks and benefits. Your PCP should know your complete medical history and can weigh in on whether or not this medication is the best choice for you.

The medication comes in a prefilled pen to inject subcutaneously (under the skin). It is given once each week without regard to food, usually on the same day of the week.

It is important to follow your doctor's dietary instructions and exercise routine while on this drug. In addition, tell your doctor if you have any major changes in your lifestyle or health status, such as a severe infection, fever, surgery or dental work. It is also important to talk to your doctor before taking semaglutide if you are pregnant or breastfeeding.

Other drugs may interact with semaglutide, including prescription and nonprescription medicines, vitamins, foods, or other natural products. Read the drug label and ask your doctor or pharmacist for a list of interactions. You should also tell your doctor if you are taking other medications to treat diabetes or high blood pressure, or if you have kidney or liver disease.

Semaglutide can slow your digestion, so it may take longer for other medications to be absorbed from the gut. This can affect the effectiveness of the other medication. It may also change the way your body absorbs alcohol, increasing the toxic effects.